5-Isopropylthiazol-2-amine

Cov khoom no feem ntau cais tawm raws li cov khoom siv crystalline xws li daj daj mus rau lub teeb ci. Nws cov mis molecular yog C6H10N2S, sib xws rau qhov hnyav molecular ntawm 142.22. Lub sijhawm melting nyob nruab nrab ntawm 138 thiab 142 degree, qhia txog kev ntim khoom siv lead ua zoo ib yam. Qhov ntsuas qhov ceev yog kwv yees li 1.15 g / cm³ ntawm chav tsev kub. Nws pom zoo solubility nyob rau hauv polar organic solvents xws li ethanol, dimethylformamide, thiab dichloromethane, thaum uas qhia me ntsis solubility nyob rau hauv dej thiab negligible affinity rau aliphatic hydrocarbons. Lub nplhaib thiazole imparts nruab nrab aromatic stability, thiab cov thawj amine yuav undergo condensation nrog carbonyl tebchaw. Cia nyob rau hauv cov thawv kaw nruj nreem nyob rau hauv inert cua ntawm qhov kub thiab txias (2-8 degree) yog pom zoo kom tiv thaiv oxidative degradation. Kev sib cuag nrog cov muaj zog oxidizing cov neeg ua haujlwm thiab cov ntxhia acids yuav tsum tau tswj hwm nrog cov txheej txheem kuaj kev ceev faj.

Lub molecular architecture ntawm 5-isopropylthiazol-2-amine muaj tsib lub nplhaib thiazole bearing ib qho isopropyl hloov ntawm 5-txoj hauj lwm thiab ib tug thawj amine ntawm 2-txoj hauj lwm. Lub thiazole nucleus, uas suav nrog ob qho tib si sulfur thiab nitrogen atoms, tsim ib qho hluav taws xob tsis muaj ntxhiab tsw uas muaj peev xwm koom nrog π-stacking kev sib cuam tshuam thiab hydrogen bonding los ntawm lub nplhaib nitrogen. Pawg isopropyl branched qhia txog tus cwj pwm hydrophobic thiab steric cawv, modulating tag nrho lipophilicity thiab conformational nyiam ntawm cov molecule. Lub exocyclic amine muab ib qhov chaw nucleophilic rau ntau yam kev hloov pauv, suav nrog kev tsim amide, txo qis alkylation, thiab diazonium chemistry. Qhov kev sib xyaw ua ke ntawm cov tub ntxhais heteroaromatic nrog ib qho alkyl sab saw thiab ib qho reactive amine ua rau cov compound muaj txiaj ntsig zoo rau kev tsim cov tshuaj lom neeg lom neeg.

Pharmaceutical Intermediate
Hauv kev tshawb nrhiav tshuaj, cov aminothiazole no yog qhov chaw pib rau kev npaj cov tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv - cov khoom inflammatory. Lub amine kov tso cai rau kev sib txuas nrog cov carboxylic acid fragments los tsim cov tsev qiv ntawv amide, thaum lub nplhaib thiazole tuaj yeem koom nrog cov xwm txheej tseem ceeb nrog cov enzyme nquag. Nws cov yam ntxwv nta tau raug siv los ntawm kev sib txuas ntawm kinase modulators qhov twg cov pab pawg isopropyl pab txhawb rau kev sib cuag hydrophobic.

Antimicrobial Agent Development
Cov derivatives ntawm qhov scaffold no tau tshawb xyuas rau kev ua haujlwm tawm tsam cov kab mob thiab cov kab mob fungal, tshwj xeeb tshaj yog cov kab mob tiv taus rau cov kev kho mob. thiazole core tuaj yeem cuam tshuam nrog microbial cell phab ntsa biosynthesis lossis cuam tshuam cov txheej txheem metabolic tseem ceeb. Kev hloov kho ntawm amine nrog ntau yam acyl lossis aryl hloov pauv tau txais txiaj ntsig cov neeg sib tw nrog nthuav dav thiab txhim kho potency hauv kev soj ntsuam preclinical.

Kev tshawb nrhiav Anticancer
Lub compound yog ua hauj lwm nyob rau hauv lub synthesis ntawm molecules ntsuam xyuas rau cytotoxic kev ua si tiv thaiv qog cell kab. Thiazole- muaj cov khoom sib txuas tau pom tias muaj peev xwm cuam tshuam rau hauv DNA lossis inhibit protein kinases koom nrog hauv kev mob qog noj ntshav. Cov qauv- kev tshawb fawb txog kev ua haujlwm nyob ib puag ncig cov isopropyl thiab amine pawg pab txhim kho kev xaiv zoo rau cov hlwb tsis zoo thaum txo qis - cov teebmeem.

Heterocyclic Synthesis Platform
Raws li lub tsev thaiv ntau yam, 5-isopropylthiazol-2-amine koom nrog hauv kev tsim kho lub nplhaib fused xws li thiazolo[4,5-d]pyrimidines los ntawm cyclocondensation nrog cov reagents tsim nyog. Cov pab pawg amine ua kom muaj kev sib koom ua ke rau hauv ntau cov qauv tsim los ntawm palladium-catalyzed cross-couplings lossis multicomponent cov tshuaj tiv thaiv. Cov elaborated heterocycles no pom cov ntawv thov hauv cov ntaub ntawv tshawb fawb thiab ua molecular probes hauv tshuaj lom neeg biology.

Cim npe nrov: 5-isopropylthiazol-2-amine, Tuam Tshoj 5-isopropylthiazol-2-amine manufacturers, lwm tus neeg