2,6-Difluoropyridin-3-amine

Cov khoom sib xyaw no feem ntau ntsib raws li cov xim dawb kom tawm -dawb crystalline khoom nrog ib qho me me, tus yam ntxwv amine tsw. Lub melting point feem ntau ntog nyob rau hauv thaj tsam ntawm 86-90 degree, qhia ib tug zoo-txhais crystalline qauv. Qhov ntsuas qhov ceev yog kwv yees li 1.42 g / cm³ nyob rau hauv cov txheej txheem kuaj mob. Nws nthuav tawm zoo solubility nyob rau hauv polar organic solvents xws li methanol, ethanol, acetone, thiab dimethyl sulfoxide, thaum pom tau tias muaj kev solubility nyob rau hauv dej thiab tsis zoo affinity rau tsis yog -polar hydrocarbons xws li hexane los yog toluene. Lub xub ntiag ntawm ob lub nplhaib nitrogen thiab amino pawg tsim cov hauv kev rau hydrogen bonding kev sib cuam tshuam uas cuam tshuam rau nws tus cwj pwm kev sib cais. Thermal stability yog txaus siab nyob rau hauv ib txwm tuav tej yam kev mob, tab sis maj mam darkening yuav tshwm sim raws li ntev raug rau huab cua thiab lub teeb. Storage in tightly sealed amber containers under an inert atmosphere at reduced temperature (2–8℃) is recommended to maintain optimal purity. Kev sib cuag nrog cov neeg muaj zog oxidizing, acid anhydrides, thiab reactive carbonyl tebchaw yuav tsum tau tswj nrog kev soj ntsuam kom zoo.

2,6-Difluoropyridin-3-amine sawv cev rau lub tswv yim fluorinated aminopyridine nyob rau hauv fluorine atoms nyob rau 2- thiab 6-txoj hauj lwm flanking lub nplhaib nitrogen, thaum ib pawg amino nyob rau ntawm 3-txoj hauj lwm ntawm pyridine nucleus. Cov qauv hloov pauv no ua rau lub cev muaj zog nrog cov yam ntxwv tshwj xeeb hauv hluav taws xob: ob lub fluorine atoms ua kom muaj zog hluav taws xob rho tawm los ntawm ob qho tib si inductive thiab resonance mechanisms, txo qhov pib ntawm ob lub nplhaib nitrogen thiab exocyclic amino pawg piv rau unsubstituted aminopyridine. Qhov tshwm sim electron-deficient heteroaromatic system qhia txhim kho kev ruaj ntseg rau oxidative degradation thaum tswj hwm nucleophilic cim txaus rau cov qauv derivatization cov tshuaj tiv thaiv. Qhov sib thooj ntawm cov amino pawg mus rau lub nplhaib nitrogen tsim lub peev xwm chelation site rau hlau ions, thaum lub symmetrical fluorine hloov pauv imparts ib tug polarized molecular nto muaj peev xwm koom nyob rau hauv kev taw qhia kev cuam tshuam nrog lom macromolecules. Qhov no compact tab sis functionally ntom heterocycle ua hauj lwm raws li ib qho tseem ceeb nkag mus rau hauv ntau yam kev hloov pauv pyridine systems uas meej tswj cov khoom siv hluav taws xob thiab hydrogen bonding peev yog qhov tseem ceeb.

Pharmaceutical Synthesis
Hauv kev siv tshuaj chemistry, fluorinated aminopyridine no feem ntau siv los ua lub tsev thaiv kev sib sau ua ke kinase inhibitors, receptor modulators, thiab cov tshuaj tua kab mob. Cov amino pawg ua kom yooj yim amide tsim nrog carboxylic acid- muaj cov tshuaj pharmacophores lossis hloov mus rau ureas thiab carbamates los ntawm cov tshuaj tiv thaiv nrog isocyanates thiab chloroformates. Tus qauv 2,6-difluoro hloov pauv tau siv los txhim kho cov metabolism hauv kev ruaj ntseg thiab txo qis kev sib cuam tshuam ntawm cov neeg siv tshuaj yeeb yam tsom rau oncology thiab kab mob sib kis. Lub nplhaib nitrogen tuaj yeem koom nrog kev sib koom ua ke rau cov hlau ions hauv metalloenzyme inhibitors lossis ua haujlwm raws li hydrogen daim ntawv cog lus lees txais hauv kev sib txuas receptor.

Agrochemical Discovery
Hauv kev tshawb nrhiav kev tiv thaiv qoob loo, qhov sib xyaw ua haujlwm no ua haujlwm tseem ceeb hauv nruab nrab rau kev sib txuas cov tshuaj tua kab tshiab, fungicides, thiab tshuaj tua kab mob nrog cov kev xaiv zoo dua. Cov hluav taws xob- tsis muaj pyridine core pab txhawb kev khi rau cytochrome P450 enzymes thiab hlau- muaj cov hom phiaj hauv cov kab mob phytopathogenic. Kev sib txuas ntawm cov aminopyridine no nrog ntau yam heterocyclic thiab aromatic cores los ntawm palladium-catalyzed amination los yog amide tsim tau ua rau muaj zog tiv thaiv kab mob ua liaj ua teb cuam tshuam rau cov qoob loo thiab zaub. Cov fluorine atoms pab txhawb rau ib puag ncig zoo persistence thaum tuav tswj tau cov yam ntxwv biodegradation.

Kev sib koom ua ke ntawm Chemistry thiab Khoom siv
Cov yam ntxwv hluav taws xob tshwj xeeb ntawm 2,6-difluoropyridin-3-amine ua rau nws muaj txiaj ntsig zoo rau engineering hlau-organic moj khaum thiab kev sib koom ua ke. Kev sib xyaw ua ke ntawm lub nplhaib nitrogen thiab exocyclic amino pawg tsim ib qho chaw chelation bidentate muaj peev xwm ua kom ruaj khov hloov pauv hlau ions hauv ntau lub xeev oxidation. Cov complexes pom daim ntawv thov nyob rau hauv catalysis, magnetic cov ntaub ntawv, thiab luminescent sensors. Cov electron rho tawm fluorine atoms modulate lub ligand teb lub zog thiab cuam tshuam cov spectroscopic zog ntawm cov hlau complexes, ua kom zoo tuning ntawm lawv cov yam ntxwv ua haujlwm.

Synthetic Methodology Development
Raws li ib tug multifunctional heteroaromatic substrate, lub compound no ua hauj lwm raws li ib tug kev sim platform rau tsim tshiab transformations nyob rau hauv aminopyridine thiab organofluorine chemistry. Qhov sib txawv reactivity ntawm txoj hauj lwm ortho thiab para rau cov amino pawg enables kev tshawb fawb nyob rau hauv regioselective electrophilic hloov thiab qhia metalation tswv yim. Cov koom haum koom nrog hauv Buchwald-Hartwig aminations, Chan-Lam couplings, thiab kev hloov pauv -hlau- dawb C-N daim ntawv cog lus tsim cov tshuaj tiv thaiv, muab kev nkag mus rau ntau hom N- hloov pauv derivatives. Nws zoo-tus qauv reactivity yam ntxwv ua rau nws muaj txiaj ntsig zoo rau txoj kev txhim kho hauv thaj chaw xws li C-H functionalization, cross-coupling cascade sequences, thiab synthesis ntawm polyheterocyclic systems los ntawm cyclization kev cuam tshuam nrog ob pawg amino thiab lub nplhaib nitrogen.

Cim npe nrov: 2,6-difluoropyridin-3-amine, Tuam Tshoj 2,6-difluoropyridin-3-amine manufacturers, lwm tus neeg