2-Bromo-3,4-difluorobenzaldehyde

Cov tshuaj no feem ntau ntsib raws li daj ntseg daj mus rau lub teeb amber crystalline khoom lossis qis - melting khoom nyob rau hauv chav tsev kub, nqa ib tug ntse, aldehyde - zoo li tsw. Lub melting point feem ntau ntog nyob rau hauv thaj tsam ntawm 54-58 degree, thaum lub boiling point yog kwv yees li ntawm 240-245℃ntawm atmospheric siab, muaj peev xwm sublimation raws li ntev cua sov. Qhov ntsuas qhov ceev kwv yees li 1.81 g / cm³ raws li tus qauv. Nws pom zoo solubility nyob rau hauv cov organic solvents xws li dichloromethane, ethyl acetate, tetrahydrofuran, thiab toluene, thaum uas qhia tsawg solubility nyob rau hauv dej thiab aliphatic hydrocarbons xws li hexane. Lub aldehyde functionality ua rau cov compound uas raug oxidation thiab polymerization raws li ntev raug rau huab cua; Yog li ntawd, cia nyob rau hauv ib qho chaw inert (nitrogen los yog argon) nyob rau hauv ib lub thawv kaw nruj nreem tiv thaiv los ntawm lub teeb ntawm qhov kub thiab txias (2-8 degree) yog pom zoo. Kev sib cuag nrog cov oxidizing muaj zog, cov hauv paus muaj zog, thiab nucleophiles xws li thawj amines yuav tsum raug zam kom tsis txhob muaj qhov tsis zoo los yog decomposition.

2-Bromo-3,4-difluorobenzaldehyde yog trisubstituted benzaldehyde derivative featuring ib bromine atom ntawm 2- txoj hauj lwm thiab ob lub fluorine atoms sib txuas nyob rau ntawm 3- thiab 4 aromatic txoj hauj lwm. Qhov kev npaj vicinal difluoro no, ua ke nrog ib qho ortho-bromine thiab ib pab pawg aldehyde, tsim ib lub molecule nrog pronounced electronic polarization thiab ntau reactive handles. Lub aldehyde carbonyl yog qhib rau nucleophilic ntxiv los ntawm electron rho tawm halogens, thaum lub bromine atom ua hauj lwm pab raws li ntau yam khub rau kev hloov-hlau-catalyzed cross couplings. Cov fluorine atoms uas nyob ib sab tsis tsuas yog hloov cov electron ceev ntawm lub nplhaib tab sis kuj muab cov chaw rau cov fluorine tshwj xeeb kev sib tshuam hauv cov chaw lom neeg. The compact yet densely functionalized architecture positions this compound as a valuable intermediate for constructing complex aromatic systems where precise control over substitution patterns and electronic properties is essential.

Pharmaceutical Synthesis
Hauv kev tshawb nrhiav tshuaj, qhov no halogenated benzaldehyde ua haujlwm tseem ceeb hauv lub tsev thaiv kev sib sau ua ke kinase inhibitors thiab G-protein coupled receptor modulators. Cov pab pawg aldehyde ua kom txo qis amination los qhia txog cov amine sab chains, thaum lub bromine atom pab txhawb Suzuki-Miyaura couplings nrog boronic acids los tsim cov qauv biaryl. 3,4-difluoro motif tau siv los tsim cov tshuaj metabolically stabilized cov neeg sib tw uas tsom rau cov kab mob hauv lub paj hlwb thiab oncology, qhov twg fluorine atoms txhim kho kev sib raug zoo los ntawm kev sib cuam tshuam ntawm dipole thiab txo oxidative degradation.

Kev tshawb fawb Agrochemical
Nyob rau hauv kev tiv thaiv qoob loo innovation, qhov sib xyaw no ua haujlwm ua ib qho nruab nrab rau kev sib txuas cov tshuaj fungicides tshiab thiab tshuaj tua kab mob nrog kev txhim kho ib puag ncig. Cov hluav taws xob- lub nplhaib tsis muaj ntxhiab tsw tuaj yeem koom nrog kev khi tshwj xeeb rau lub hom phiaj enzymes xws li succinate dehydrogenase hauv cov kab mob fungal. Lub aldehyde kov tso cai rau kev koom ua ke ntawm oxime ether los yog hydrazone moieties uas tuaj yeem ua raws li cov nroj tsuag cov cim qhia txog cov molecules, thaum lub bromine ua rau lig -theem diversification kom optimize kev ua si tiv thaiv cov nroj tsuag resistant thiab fungal hom.

Khoom siv Science Applications
Cov yam ntxwv hluav taws xob tshwj xeeb ntawm 2-bromo-3,4-difluorobenzaldehyde ua rau nws muaj txiaj ntsig rau kev tsim cov organic semiconductors thiab cov khoom siv kho qhov muag uas tsis yog-linear. Cov hluav taws xob- rho tawm fluorine atoms txo qis lub zog molecular orbital zog, ua kom yooj yim thauj cov hluav taws xob hauv n- cov ntaub ntawv rau cov organic teb-tshuaj cuam tshuam transistors. Cov pab pawg aldehyde tuaj yeem ua tus taw tes rau kev ua haujlwm ntawm qhov chaw, thaum lub bromine atom tso cai covalent koom ua ke rau hauv cov polymers ntawm kev sib txuas sib txuas polymerization, ua kom zoo-tuning ntawm optoelectronic zog.

Organic Synthesis Building Block
Raws li ib tug multifunctional aromatic synthon, lub compound no koom nyob rau hauv ib tug dav array ntawm transformations tshaj cov pa cross -coupling. Cov aldehyde tau txais Wittig olefination, Horner-Wadsworth-Emmons cov tshuaj tiv thaiv, thiab Grignard ntxiv rau kev nkag mus rau allylic alcohols thiab styrene derivatives. Lub bromine atom koom nrog Heck cov tshuaj tiv thaiv, Sonogashira couplings, thiab halogen-hloov pauv rau tsim cov organometallic intermediates. Lub ortho-kev sib raug zoo ntawm bromine thiab fluorine ua rau muaj kev tshawb fawb nyob rau hauv kev qhia ortho-metalation thiab sequential functionalization, ua rau cov compound no yog ib qho tseem ceeb substrate rau txoj kev loj hlob nyob rau hauv cov cheeb tsam xws li C-H activation thiab cascade cyclization tshwm sim.

Cim npe nrov: Tuam Tshoj 2-bromo-3,4-difluorobenzaldehyde manufacturers, lwm tus neeg