4-Cyano-2,6-difluorobenzoic Acid

4-Cyano-2,6-difluorobenzoic acid embodies ib triply functionalized benzene nplhaib qhov twg carboxylic acid nyob rau hauv 1-txoj hauj lwm, ib pab pawg neeg nitrile nyob rau ntawm 4-txoj hauj lwm, thiab fluorine atoms symmetrically pov tseg ntawm 2- thiab 6-txoj hauj lwm. Cov qauv hloov pauv no tsim cov molecule nrog cov lus hais tsis txaus electron thoob plaws lub cev muaj zog vim yog kev sib koom ua ke ntawm electron rho tawm los ntawm fluorine atoms thiab pawg nitrile. Lub carboxylic acid moiety muab ib tug kov rau amide coupling los yog esterification, thaum lub nitrile ua ib tug precursor rau tetrazoles, amidines, los yog thawj amines los ntawm kev txo los yog hydration. Ob lub fluorine atoms, muab tso rau hauv ortho rau carboxylic acid, ua rau muaj zog inductive nyhuv uas txo qis pKa ntawm carboxylic acid piv rau unsubstituted benzoic acid, txhim khu nws muaj peev xwm mus koom nyob rau hauv ionic kev sib cuam tshuam ntawm physiological pH. Qhov kev ua haujlwm hnyav ntawm benzoic acid derivative ua haujlwm ua haujlwm ntau yam rau kev tsim cov bioactive molecules qhov twg cov khoom siv hluav taws xob muaj tseeb thiab ntau lub ntsiab lus ntawm kev sib txawv yog xav tau.

Pharmaceutical Synthesis
Hauv cov kev pabcuam tshuaj chemistry, cov tshuaj no tau siv dav los ua lub tsev thaiv kev tsim cov enzyme inhibitors thiab receptor modulators. Cov pab pawg carboxylic acid tso cai rau kev koom ua ke rau hauv cov tshuaj pharmacophores ntawm amide linkages, thaum cov nitrile tuaj yeem koom nrog hydrogen bonding nrog cov protein active sites los yog ua ib tug tuav rau ntxiv elaboration rau heterocycles xws li tetrazoles - bioisosteres ntawm carboxylic acids. Tus qauv 2,6-difluoro hloov pauv tau ua pov thawj tshwj xeeb tshaj yog muaj txiaj ntsig hauv kev tsim cov kinase inhibitors thiab cov tshuaj tiv thaiv nflammatory, qhov twg cov fluorine atoms txhim kho cov metabolism hauv kev ruaj ntseg thiab cov membrane permeability thaum pab txhawb rau lub hom phiaj khi kev sib raug zoo los ntawm kev sib raug zoo ntawm halogen.

Agrochemical R & D
Hauv kev tshawb fawb txog kev tiv thaiv qoob loo, qhov kev ua haujlwm ntawm benzoic acid ua haujlwm yog qhov tseem ceeb nruab nrab rau kev sib txuas cov tshuaj tua kab mob tshiab thiab cov tshuaj fungicides. Cov pab pawg nitrile yog ib qho motif hauv auxin- hom tshuaj tua kab mob, thaum cov carboxylic acid ua rau ntsev tsim rau kev tsim kom zoo. Cov hluav taws xob- lub nplhaib uas tsis muaj ntxhiab tsw ua kom yooj yim rau kev khi rau lub hom phiaj enzymes xws li protoporphyrinogen oxidase nyob rau hauv cov nroj tsuag los yog succinate dehydrogenase hauv fungi. Coupling no scaffold nrog ntau yam amines los yog alcohols tau yielded cov neeg sib tw nrog muaj zog kev ua si tiv thaiv cov teeb meem ua liaj ua teb kab thaum tuav tswj ib puag ncig zoo profiles.

Material Science
Cov yam ntxwv hluav taws xob tshwj xeeb ntawm 4-cyano-2,6-difluorobenzoic acid ua rau nws muaj txiaj ntsig zoo rau kev tsim cov khoom siv ua haujlwm siab, suav nrog hlau-organic moj khaum (MOFs) thiab kev sib koom tes polymers. Cov pab pawg carboxylic acid thiab nitrile tuaj yeem ua qhov chaw sib koom ua ke rau cov hlau ions, ua kom muaj kev tsim cov khoom ntxeem tau nrog cov pore qhov ntau thiab tsawg thiab chemistry nto. Nws lub tshuab hluav taws xob tsis muaj ntxhiab tsw kuj pom daim ntawv thov hauv kev sib txuas ntawm nonlinear optical chromophores thiab cov organic semiconductors qhov xav tau txais hluav taws xob muaj zog.

Organic Synthesis Building Block
Raws li ib tug multifunctional aromatic synthon, no compound koom nyob rau hauv ntau yam transformations tshaj tus qauv amide daim ntawv cog lus. Cov pab pawg nitrile tuaj yeem ua rau cov tshuaj tiv thaiv cycloaddition kom nkag mus rau tetraazoles thiab oxazoles, lossis txo qis rau cov benzylamine sib raug rau kev ua haujlwm ntxiv. Cov carboxylic acid ua rau cov lus qhia ortho-metalation tswv yim rau kev qhia ntxiv cov khoom hloov, thaum lub fluorine atoms qhib lub nplhaib mus rau nucleophilic aromatic hloov, tso cai hloov pauv hloov mus ua cov tsev qiv ntawv ntawm polysubstituted benzoic acid derivatives rau txoj kev loj hlob thiab ntuj tsim.

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