N-(2-Chloropyridin-4-yl)acetamide

Qhov kev sib xyaw no feem ntau tau txais los ua cov dawb rau tawm -dawb crystalline hmoov. Nws cov mis molecular yog C7H7ClN2O, sib xws rau qhov hnyav molecular ntawm 170.60. Lub melting point feem ntau ntog nyob rau hauv thaj tsam ntawm 128-132 degree. Qhov ntsuas qhov ceev yog kwv yees li 1.40 g / cm³ nyob rau hauv ambient tej yam kev mob. Nws yog me ntsis soluble nyob rau hauv cov organic solvents xws li ethanol, acetone, thiab ethyl acetate, sparingly soluble nyob rau hauv dichloromethane, thiab xyaum insoluble nyob rau hauv dej thiab tsis polar solvents zoo li hexane. Cov molecule nta ib lub nplhaib pyridine hloov ntawm 4 txoj hauj lwm nrog ib pawg acetamido, uas nws tus kheej nqa cov tshuaj chlorine atom ntawm 2 txoj hauj lwm ntawm pyridine. Qhov kev sib txuas ntawm amide yog raug rau hydrolysis nyob rau hauv cov kua qaub los yog yooj yim. Kev khaws cia rau hauv lub thawv kaw nruj nreem tiv thaiv los ntawm lub teeb thiab noo noo ntawm qhov ntsuas kub txaus; desiccated tej yam kev mob raug pom zoo rau lub sij hawm ntev. Kev sib cuag nrog cov neeg muaj zog oxidizing thiab cov hauv paus muaj zog yuav tsum zam.

N-(2-Chloropyridin-4-yl)acetamide yog ib qho yooj yim tab sis ua haujlwm cuam tshuam amide muab los ntawm 4-amino-2-chloropyridine. Cov molecule sib txuas cov electron tsis muaj pyridine nplhaib bearing chlorine atom ortho mus rau qhov chaw ntawm kev txuas nrog ib pawg acetamide. Cov qauv hloov pauv no tsim cov polar, hydrogen bonding amide muaj peev xwm cuam tshuam nrog cov hom phiaj lom neeg, thaum cov tshuaj chlorine imparts lipophilicity thiab tuaj yeem ua tus tuav rau kev ua haujlwm ntxiv los ntawm nucleophilic aromatic hloov pauv lossis kev sib txuas sib txuas. Lub pyridine nitrogen muaj peev xwm ntxiv hydrogen daim ntawv cog lus. Nws cov qauv compact thiab sib npaug physicochemical zog ua rau nws muaj txiaj ntsig nruab nrab hauv kev tsim kho ntawm ntau cov molecules, tshwj xeeb tshaj yog nyob rau hauv tshuaj chemistry qhov twg 2 chloropyridine motif tshwm nyob rau hauv ntau yam pharmacologically active compounds.

Pharmaceutical Intermediate
Hauv kev tshawb nrhiav tshuaj, cov tshuaj chloropyridine acetamide no yog siv los ua lub tsev thaiv rau kev sib txuas ntawm kinase inhibitors, tshuaj tua kab mob, thiab lwm yam kev kho mob. Cov pab pawg amide tuaj yeem raug txo qis rau cov amine sib raug lossis siv ncaj qha rau hauv kev sib txuas lus, thaum cov tshuaj chlorine atom tso cai rau palladium catalyzed cross couplings xws li Suzuki lossis Buchwald-Hartwig cov tshuaj tiv thaiv los qhia ntau yam aryl lossis heteroaryl hloov pauv. Cov derivatives npaj los ntawm qhov scaffold no tau tshawb nrhiav rau lawv cov haujlwm muaj peev xwm tiv thaiv kab mob qog noj ntshav thiab kis kab mob.

Kev tshawb fawb Agrochemical
Qhov kev sib xyaw no ua haujlwm ua ntej hauv kev txhim kho cov tshuaj fungicides tshiab thiab tshuaj tua kab. Pyridine derivatives muaj nyob rau hauv agrochemicals tsom kab nicotinic acetylcholine receptors los yog fungal enzymes. Cov acetamide moiety tuaj yeem hloov kho kom zoo rau kev ua haujlwm lom neeg, thaum cov tshuaj chlorine muab ib qho chaw rau ntxiv derivatization kom zoo lipophilicity thiab ib puag ncig persistence.

Tsev Block rau Heterocyclic Systems
Kev sib raug zoo ntawm cov tshuaj chlorine thiab amide nitrogen ua rau kev tsim kho ntawm fused heterocyclic systems xws li imidazo[1,2 a]pyridines thiab pyrido[2,3 d]pyrimidines los ntawm cyclization cov tshuaj tiv thaiv. Cov txheej txheem nplhaib no raug tshawb xyuas rau lawv cov khoom siv tshuaj, nrog rau cov tub ntxhais pyridine nruj muab cov kev txwv tsis pub muaj txiaj ntsig zoo rau kev lees paub lub hom phiaj.

Organic Synthesis Intermediate
Raws li ntau yam khoom siv nruab nrab, N-(2-chloropyridin-4-yl)acetamide koom nrog ntau yam kev hloov pauv xws li nucleophilic aromatic hloov, palladium catalyzed cross couplings, thiab txo amide. Cov acetamide tuaj yeem ua rau hydrolyzed rau cov amine sib raug rau kev ua haujlwm ntxiv, thiab cov tshuaj chlorine ua rau kev qhia txog ntau yam nucleophiles. Nws cov khoom siv txuas ntxiv mus rau kev sib txuas ntawm cov khoom siv ua haujlwm thiab cov kev sojntsuam molecular uas lub nplhaib pyridine muab cov khoom siv hluav taws xob thiab hydrogen bonding uas xav tau.

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