5-Acetyl-2-methylpyridine

Qhov sib xyaw no feem ntau ntsib raws li cov kua tsis muaj xim rau daj daj daj ntawm qhov kub thiab txias, muaj tus yam ntxwv pyridine- zoo li tsw nrog qab zib, nutty undertones. Nws cov mis molecular yog C8H9NO, sib xws rau qhov hnyav molecular ntawm 135.16. Cov ntsiab lus kub yog kwv yees li 220-225℃ntawm atmospheric siab, nrog rau kev xam qhov ceev ze ntawm 1.06 g / cm³ ntawm 20 degree. Nws yog dawb do miscible nrog cov organic solvents xws li ethanol, acetone, ethyl acetate, thiab dichloromethane, thaum qhia me ntsis solubility hauv dej thiab txwv solubility hauv aliphatic hydrocarbons. Cov molecule nta ib lub nplhaib pyridine hloov nrog ib pawg acetyl ntawm 5-txoj hauj lwm thiab ib pawg methyl ntawm 2-txoj hauj lwm. Cov acetyl carbonyl muaj kev cuam tshuam rau nucleophilic ntxiv thiab condensation cov tshuaj tiv thaiv, thaum lub pyridine nitrogen muab kev yooj yim thiab muaj peev xwm sib koom ua ke. Kev khaws cia hauv cov thawv kaw nruj nreem tiv thaiv los ntawm lub teeb thiab noo noo ntawm qhov kub thiab txias yog feem ntau txaus, txawm tias qhov txias cia tau pom zoo rau lub sijhawm ntev. Kev sib cuag nrog cov neeg muaj zog oxidizing thiab cov hauv paus muaj zog yuav tsum zam.

5-Acetyl-2-methylpyridine yog ib qho kev hloov pauv ntawm pyridine derivative sib txuas ua ke methyl pawg ntawm 2-txoj hauj lwm thiab ib pawg acetyl ntawm 5-txoj hauj lwm ntawm lub nplhaib heteroaromatic. Cov tub ntxhais pyridine imparts electron deficiency los ntawm lub nplhaib nitrogen, uas cuam tshuam cov reactivity ntawm pawg acetyl, ua rau nws ntau electrophilic tshaj nyob rau hauv benzene analogs. methyl pawg pab txhawb electron ceev los ntawm hyperconjugation thiab steric hindrance, thaum lub acetyl muab ib tug ntau yam kov rau ntxiv transformations xws li condensation nrog amines, hydrazines, thiab active methylene tebchaw. Kev sib cais ntawm ob qho tib si tso cai rau kev xaiv ua haujlwm ntawm qhov chaw acetyl yam tsis muaj kev cuam tshuam los ntawm pawg methyl. Qhov kev sib xyaw ua ke ntawm ib qho yooj yim heterocycle thiab cov pa roj carbonyl reactive ua rau qhov sib xyaw ua ke muaj txiaj ntsig nruab nrab hauv kev sib xyaw ntawm cov tshuaj, agrochemicals, thiab cov tshuaj tsw qab, qhov twg lub nplhaib pyridine tuaj yeem koom nrog hydrogen bonding thiab π-stacking kev sib cuam tshuam thaum lub acetyl enables derivatization.

Pharmaceutical Intermediate
Qhov no acetylpyridine derivative yog ua hauj lwm nyob rau hauv lub synthesis ntawm cov tshuaj tsom mus rau lub paj hlwb thiab o. Cov pab pawg acetyl tuaj yeem hloov mus rau ntau yam tshuaj pharmacophores los ntawm kev sib xyaw ua ke, txo qis, lossis oxidation, thaum lub nplhaib pyridine pab txhawb kev sib khi los ntawm hydrogen bonding thiab π- kev cuam tshuam. Nws tau raug siv rau hauv kev npaj ntawm nicotinic receptor modulators thiab tiv thaiv -tubercular cov neeg ua haujlwm, qhov twg methyl pawg txhim kho lipophilicity rau kev txhim kho daim nyias nyias.

Flavour thiab Fragrance Ingredient
Cov khoom xyaw muaj cov yam ntxwv ci, nutty, thiab paj kws - zoo li aroma, ua rau nws muaj txiaj ntsig zoo li tus neeg sawv cev hauv cov khoom noj xws li cov khoom ci, khoom noj txom ncauj, thiab dej haus. Nws txhawb nqa cov ntawv sau tseg hauv cov khoom noj uas tau ua tiav thiab siv rau hauv cov lej txhawm rau txhim kho kev hnov ​​​​lus zoo. Nws stability nyob rau hauv thermal ua tej yam kev mob ua rau nws haum rau siv nyob rau hauv ci thiab kib daim ntaub ntawv.

Agrochemical Building Block
Hauv kev tshawb nrhiav kev tiv thaiv qoob loo, qhov pyridine derivative ua haujlwm ua ntej rau kev sib txuas tshuaj tua kab thiab fungicides. Lub nplhaib pyridine yog ib qho motif hauv cov tshuaj tua kab neonicotinoid, qhov uas nws cuam tshuam nrog nicotinic acetylcholine receptors hauv kab. Cov pab pawg acetyl tso cai rau kev sib txuas ntawm ntau yam toxophores los ntawm kev sib xyaw lossis txo qis, ua kom muaj txiaj ntsig zoo ntawm kev ua haujlwm lom neeg thiab ib puag ncig persistence.

Organic Synthesis Intermediate
Raws li lub tsev thaiv ntau yam, 5-acetyl-2-methylpyridine koom nrog ntau yam kev hloov pauv xws li aldol condensations, Mannich cov tshuaj tiv thaiv, thiab txo cov aminations. Cov acetyl tuaj yeem txo qis rau cov cawv lossis ethyl pawg, oxidized rau carboxylic acid, lossis hloov mus rau enamines rau kev ua haujlwm ntxiv. Cov pyridine nitrogen tuaj yeem coj cov tshuaj tiv thaiv ortho-metalation los yog ua haujlwm li ligand hauv cov txheej txheem hlau-catalyzed. Nws cov khoom siv txuas ntxiv mus rau kev sib txuas ntawm heterocyclic systems xws li pyrido [2,3-d] pyrimidines thiab imidazo [1,2-a] pyridines los ntawm cyclocondensation cov tshuaj tiv thaiv.

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