4,6-Dimethoxypyrimidine-5-carboxylic Acid

Qhov kev sib xyaw no feem ntau cais tawm raws li cov xim dawb kom tawm -dawb crystalline khoom. Nws cov mis molecular yog C7H8N2O4, sib xws rau qhov hnyav molecular ntawm 184.15. Lub melting point feem ntau ntog nyob rau hauv thaj tsam ntawm 148-152 degree, feem ntau nrog decomposition pom raws li ntev cua sov. Qhov ntsuas qhov ceev yog kwv yees li 1.42 g / cm³ nyob rau hauv ambient tej yam kev mob. Nws pom zoo solubility nyob rau hauv polar organic solvents xws li methanol, ethanol, thiab dimethyl sulfoxide, thaum uas qhia me ntsis solubility nyob rau hauv ethyl acetate thiab txwv solubility nyob rau hauv dej thiab tsis yog -polar solvents xws li dichloromethane thiab hexane. Cov molecule muaj ib lub nplhaib pyrimidine nrog ob pawg methoxy ntawm 4-thiab 6-txoj hauj lwm thiab carboxylic acid ntawm 5-txoj hauj lwm. Cov carboxylic acid yog raug rau deprotonation, esterification, thiab amide tsim, thaum cov methoxy pawg nyob ruaj khov nyob rau hauv feem ntau cov mob. Kev khaws cia rau hauv cov thawv kaw nruj nreem tiv thaiv los ntawm lub teeb thiab noo noo ntawm qhov kub thiab txias yog feem ntau txaus, txawm hais tias desiccated tej yam kev mob raug pom zoo rau kev cia ntev. Kev sib cuag nrog cov neeg muaj zog oxidizing thiab cov hauv paus muaj zog yuav tsum zam.

4,6-Dimethoxypyrimidine-5-carboxylic acid yog trisubstituted pyrimidine derivative uas muaj ob lub electron{15}} pub dawb pab pawg methoxy thiab ib qho hluav taws xob- rho carboxylic acid ntawm lub nplhaib heteroaromatic. Cov tub ntxhais pyrimidine, nrog nws ob lub nitrogen atoms ntawm txoj haujlwm 1 thiab 3, muab cov hluav taws xob nruab nrab -tsis muaj ntxhiab tsw muaj peev xwm los koom nrog hydrogen bonding thiab hlau sib koom tes. Cov pab pawg methoxy ntawm 4- thiab 6-txoj hauj lwm pub dawb electron ceev los ntawm resonance, cuam tshuam rau kev faib hluav taws xob thiab kev ua haujlwm ntawm lub nplhaib. Cov carboxylic acid ntawm 5-txoj hauj lwm muaj ntau yam kov rau kev ua haujlwm ntxiv los ntawm kev tsim cov ntawv cog lus amide, esterification, lossis ntsev tsim. Qhov kev sib xyaw ua ke ntawm cov khoom siv hluav taws xob nplua nuj thiab cov hluav taws xob tsis muaj hluav taws xob tsim kom muaj lub zog rub tawm uas tuaj yeem cuam tshuam rau ob qho tib si tshuaj reactivity thiab kev paub txog roj ntsha. Cov khoom siv ua haujlwm tseem ceeb hauv tsev kho mob hauv tshuaj chemistry thiab kev tshawb fawb agrochemical rau kev tsim cov pyrimidine-raws li molecules complex, qhov twg cov methoxy pawg tuaj yeem hloov kho cov khoom siv physicochemical thiab carboxylic acid muab cov ntsiab lus txuas rau cov tshuaj pharmacophoric.

Pharmaceutical Intermediate
Hauv kev tshawb nrhiav tshuaj, qhov no pyrimidine carboxylic acid yog ua haujlwm los ua lub tsev thaiv rau kev sib xyaw kinase inhibitors thiab cov tshuaj tua kab mob. Cov carboxylic acid ua kom yooj yim amide coupling nrog amine - muaj cov tshuaj pharmacophores, thaum cov pab pawg methoxy tuaj yeem cuam tshuam cov metabolic stability thiab khi affinity los ntawm hluav taws xob los. Pyrimidine derivatives npaj los ntawm qhov scaffold no tau qhia txog kev ua haujlwm tawm tsam ntau lub hom phiaj kho mob, suav nrog cov enzymes koom nrog nucleotide synthesis thiab teeb liab txoj hauv kev.

Tsev Block rau Heterocyclic Synthesis
Lub compound ua haujlwm ua ntej rau kev tsim fused heterocyclic systems xws li pyrimido[4,5-d]pyrimidines thiab pteridines los ntawm cyclocondensation cov tshuaj tiv thaiv. Cov pab pawg electron-donating methoxy tuaj yeem hloov mus rau lwm yam haujlwm lossis khaws cia kom cuam tshuam cov khoom siv hluav taws xob ntawm cov txiaj ntsig heterocycles. Cov txheej txheem nplhaib no raug tshawb xyuas rau lawv cov khoom siv tshuaj, nrog rau cov tub ntxhais pyrimidine nruj muab cov kev txwv tsis pub muaj txiaj ntsig zoo rau lub hom phiaj paub.

Kev tshawb fawb txog Agrochemical
Hauv kev tiv thaiv qoob loo chemistry, qhov no pyrimidine derivative yog siv nyob rau hauv txoj kev loj hlob ntawm tshiab herbicides thiab fungicides. Cov pab pawg methoxy txhim kho lipophilicity rau kev txhim kho cuticle nkag mus, thaum carboxylic acid tso cai rau ntsev tsim rau kev tsim kho kom zoo. Pyrimidine-raws li agrochemicals feem ntau tsom cov enzymes tseem ceeb hauv cov nroj tsuag metabolic txoj hauv kev, xws li acetolacate synthase, thiab cov scaffold no muab lub sijhawm rau kev tsim cov tebchaw nrog kev xaiv ua haujlwm tawm tsam cov nroj tsuag muaj teeb meem.

Organic Synthesis Building Block
Raws li ntau yam khoom siv nruab nrab, 4,6-dimethoxypyrimidine-5-carboxylic acid koom nrog ntau yam kev hloov pauv xws li esterification, amide coupling, thiab nucleophilic aromatic hloov (tom qab ua kom lub nplhaib pyrimidine). Cov pab pawg methoxy tuaj yeem raug xaiv demethylated raws li qhov tsim nyog los qhia hydroxyl rau kev ua haujlwm ntxiv. Nws cov khoom siv txuas ntxiv mus rau kev sib txuas ntawm ligands rau cov hlau complexes thiab cov khoom siv ua haujlwm uas lub nplhaib pyrimidine muab cov khoom tsim nyog xws li kev sib koom tes hlau thiab hydrogen-bonding peev.

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