3-Bromo-4-chlorophenol

Cov tshuaj no feem ntau tau txais los ntawm cov khoom siv crystalline xws li tawm -dawb mus rau lub teeb ci. Nws cov mis molecular yog C6H4BrClO, sib xws rau qhov hnyav molecular ntawm 207.45. Lub melting point feem ntau ntog nyob rau hauv thaj tsam ntawm 62-66 degree. Qhov ntsuas qhov ceev yog kwv yees li 1.86 g / cm³ nyob rau hauv ambient tej yam kev mob. Nws pom zoo solubility nyob rau hauv cov organic solvents xws li methanol, ethanol, acetone, thiab ethyl acetate, thaum uas qhia txog solubility nyob rau hauv dej thiab nruab nrab solubility nyob rau hauv tsis muaj polar solvents xws li dichloromethane thiab toluene. Lub molecule muaj ib lub nplhaib phenol nrog ib tug bromine atom ntawm 3 txoj hauj lwm thiab ib tug chlorine atom ntawm 4 txoj hauj lwm. Lub phenolic hydroxyl yog acidic thiab tuaj yeem koom nrog hydrogen bonding, thaum ob qho tib si halogen atoms tau qhib rau nucleophilic aromatic hloov pauv thiab hloov pauv hlau catalyzed cross coupling tshua. Kev khaws cia rau hauv cov thawv kaw nruj nreem tiv thaiv los ntawm lub teeb thiab noo noo ntawm qhov kub thiab txias yog feem ntau txaus, txawm hais tias desiccated tej yam kev mob raug pom zoo rau lub sij hawm ntev. Kev sib cuag nrog cov oxidizing muaj zog, cov hauv paus muaj zog, thiab cov kua qaub chlorides yuav tsum raug zam.

3 Bromo 4 chlorophenol yog disubstituted phenol derivative uas muaj ob qho tib si bromine thiab chlorine atoms ntawm lub nplhaib uas muaj ntxhiab hauv 1,2 kev sib raug zoo ntawm ib leeg, nrog rau pawg hydroxyl ntawm 1 txoj hauj lwm. phenol core muab cov kua qaub proton muaj peev xwm ntawm hydrogen bonding thiab hlau sib koom tes, thaum lub electron tshem tawm halogens modulate acidity ntawm pawg hydroxyl thiab cuam tshuam rau tag nrho cov hluav taws xob faib. Lub bromine atom ntawm 3 txoj hauj lwm thiab cov tshuaj chlorine ntawm 4 txoj hauj lwm muab orthogonal leeg rau kev ua haujlwm ua ntu zus los ntawm palladium catalyzed cross coupling tshua, nrog cov bromine feem ntau ua rau muaj zog dua vim cov pa roj carbon halogen tsis muaj zog. Cov qauv hloov pauv no ua rau lub cev muaj zog polarized qhov twg cov halogens tuaj yeem ncaj qha kev hloov hluav taws xob thiab qhib cov haujlwm tshwj xeeb rau kev tawm tsam nucleophilic. Kev sib xyaw ua ke ntawm kev hloov pauv phenol thiab ob qhov sib txawv halogen tuav ntawm qhov sib xyaw ua kom muaj ntxhiab tsw qab ua rau cov khoom sib xyaw ua kom muaj txiaj ntsig zoo hauv cov tshuaj chemistry, kev tshawb fawb agrochemical, thiab cov ntaub ntawv tshawb fawb rau kev tsim cov molecules ntau dua nrog cov khoom siv hluav taws xob thiab cov khoom tsis zoo.

Pharmaceutical Intermediate
Qhov no halogenated phenol yog ua hauj lwm nyob rau hauv lub synthesis ntawm ntau yam tshuaj, nrog rau cov tshuaj tiv thaiv kab mob thiab enzyme inhibitors. phenolic hydroxyl ua kom yooj yim ether tsim nrog alkyl halides lossis esterification nrog carboxylic acids, thaum lub bromine thiab chlorine atoms tso cai rau kev sib txuas sib txuas ua ke los qhia ntau haiv neeg aryl, heteroaryl, lossis amino pawg. Cov hluav taws xob tshem tawm halogens tuaj yeem hloov kho cov acidity thiab hydrogen bonding peev xwm ntawm phenol, cuam tshuam kev sib cuam tshuam nrog cov hom phiaj lom neeg.

Tsev Blocks rau Agrochemicals
Hauv kev tiv thaiv kev tiv thaiv qoob loo, qhov sib xyaw no ua haujlwm ua ntej rau kev tsim cov tshuaj fungicides tshiab thiab tshuaj tua kab mob. Halogenated phenols yog ib qho motifs nyob rau hauv agrochemicals uas cuam tshuam cov fungal membrane kev ncaj ncees los yog inhibit qhov tseem ceeb enzymes hauv cov nroj tsuag metabolic txoj kev. Cov bromine thiab chlorine atoms ua kom zoo kho ntawm lipophilicity thiab cov khoom siv hluav taws xob los txhim kho lub hom phiaj affinity thiab ib puag ncig persistence, thaum lub phenol muab ib tug kov rau ntxiv derivatization los ntawm ester los yog ether tsim.

Precursor rau cov khoom siv ua haujlwm
Cov tub ntxhais uas muaj ntxhiab tsw zoo thiab cov leeg halogen orthogonal ua rau cov khoom siv no muaj txiaj ntsig zoo rau kev tsim cov kua dej crystalline thiab cov organic semiconductors. Kev koom ua ke rau hauv kev sib txuas ntawm cov polymers los ntawm kev sib txuas sib txuas polymerization yields cov ntaub ntawv nrog cov khoom siv optoelectronic tunable rau kev siv hauv cov organic teb cov nyhuv transistors thiab cov khoom siv photovoltaic. Cov pab pawg phenol tuaj yeem siv los qhia txog cov saw hlau solubilizing lossis thauj cov ntaub ntawv mus rau qhov chaw.

Organic Synthesis Building Block
Raws li ntau yam khoom siv nruab nrab, 3 bromo 4 chlorophenol koom nrog ntau yam kev hloov pauv xws li Ullmann couplings, Suzuki Miyaura cov tshuaj tiv thaiv, thiab nucleophilic aromatic hloov. Qhov sib txawv ntawm qhov sib txawv ntawm ob lub halogens ua rau muaj kev ua haujlwm ua ntu zus: bromine tuaj yeem koom nrog kev sib txuas sib txuas thaum cov tshuaj chlorine tseem tsis zoo rau tom qab elaboration. Cov phenol tuaj yeem tiv thaiv raws li ether lossis ester los hloov pauv kev ua haujlwm thaum lub sijhawm sib xyaw ua ke. Nws cov khoom siv txuas ntxiv mus rau kev sib txuas ntawm cov khoom siv ntuj tsim analogs thiab cov khoom siv ua haujlwm uas yuav tsum muaj kev tswj xyuas cov qauv hloov pauv ntawm lub nplhaib aromatic.

Cim npe nrov: Tuam Tshoj 3-bromo-4-chlorophenol manufacturers, lwm tus neeg