1-(4-Chlorophenyl) urea

Qhov kev sib xyaw no feem ntau tau txais los ua cov dawb rau tawm -dawb crystalline hmoov. Nws cov mis molecular yog C7H7ClN2O, sib xws rau qhov hnyav molecular ntawm 170.60. Lub melting point feem ntau ntog nyob rau hauv thaj tsam ntawm 205-209 degree, feem ntau nrog decomposition pom raws li ntev cua sov. Nws yog me ntsis soluble nyob rau hauv polar organic solvents xws li ethanol thiab acetone, sparingly soluble nyob rau hauv dichloromethane thiab ethyl acetate, thiab xyaum insoluble nyob rau hauv dej thiab tsis polar solvents zoo li hexane. Cov molecule muaj urea moiety txuas rau lub nplhaib 4-chlorophenyl. Cov pab pawg urea tuaj yeem koom nrog kev sib koom ua ke ntawm hydrogen los ntawm ob tus neeg pub dawb NH thiab cov neeg txais carbonyl, thaum cov tshuaj chlorine atom muab tus kov rau kev ua haujlwm ntxiv. Kev khaws cia rau hauv lub thawv kaw nruj nreem tiv thaiv los ntawm lub teeb thiab noo noo ntawm qhov kub thiab txias yog feem ntau txaus. Kev sib cuag nrog cov neeg muaj zog oxidizing thiab muaj zog acids yuav tsum zam.

1-(4-Chlorophenyl) urea yog ib qho yooj yim diarylurea derivative nyob rau hauv uas ib tug 4-chlorophenyl nplhaib yog ncaj qha txuas mus rau ib tug nitrogen ntawm urea functional pawg. Lub urea moiety yog ib qho tshuaj muaj cai muaj peev xwm tsim tau ntau yam hydrogen bonds nrog lub hom phiaj lom neeg, feem ntau ua haujlwm ua haujlwm tseem ceeb hauv cov enzyme inhibitors thiab receptor ligands. Lub para-chlorophenyl hloov pauv qhia cov cim electron rho tawm thiab lipophilicity, uas tuaj yeem hloov kho ob qho tib si hydrogen-bonding peev txheej ntawm urea thiab tag nrho cov khoom siv hluav taws xob ntawm lub cev. Cov tshuaj chlorine atom muab qhov chaw rau kev ua haujlwm ntxiv los ntawm nucleophilic aromatic hloov pauv lossis kev sib txuas sib txuas. Qhov no compact, bifunctional scaffold yog qhov tseem ceeb nyob rau hauv tshuaj chemistry thiab agrochemical tshawb fawb raws li ib tug intermediate rau tsim ntau complex molecules nrog tej yam kev mob lom.

Pharmaceutical Intermediate
Qhov no urea derivative yog ua hauj lwm nyob rau hauv lub synthesis ntawm cov tebchaw uas muaj peev xwm anticancer, anti-inflammatory, thiab anticonvulsant kev ua ub no. Cov urea moiety tuaj yeem ua haujlwm raws li hydrogen- kev sib txuas motif hauv enzyme inhibitors, tshwj xeeb tshaj yog cov hom phiaj kinases thiab proteases. Cov tshuaj chlorine atom ua rau lig-theem diversification los ntawm cross-coupling kev cuam tshuam, tso cai rau kev tshawb fawb ntawm cov qauv- kev sib raug zoo. Cov derivatives npaj los ntawm qhov scaffold no tau tshawb xyuas raws li kev hloov pauv ntawm ntau lub hom phiaj lom neeg.

Kev tsim kho tshuaj ntsuab
Hloov phenylureas yog ib chav kawm tseem ceeb ntawm cov tshuaj tua kab mob uas inhibit photosynthesis los ntawm kev thaiv cov electron thauj hauv photosystem II. Qhov sib xyaw no ua haujlwm tseem ceeb hauv kev tsim cov tshuaj tua kab mob, nrog kev hloov kho ntawm urea nitrogen thiab cov nplhaib uas muaj ntxhiab uas cuam tshuam rau kev xaiv thiab muaj zog tiv thaiv cov nroj tsuag thaum tswj kev nyab xeeb ntawm qoob loo. Cov tshuaj chlorine atom pab txhawb rau ib puag ncig kev ruaj ntseg thiab lipophilicity rau kev txhim kho cuticle nkag.

Tsev Blocks rau Supramolecular Chemistry
Cov pab pawg urea muaj npe nrov rau nws lub peev xwm tsim tau zoo -txhais hydrogen- kev sib koom ua ke, suav nrog cov gels, organogels, thiab crystalline networks. 1-(4-Chlorophenyl) urea ua cov qauv sib xyaw rau kev kawm urea nws tus kheej sib dhos thiab tsim cov khoom supramolecular nrog cov khoom siv. Cov tshuaj chlorine atom tuaj yeem cuam tshuam rau cov khoom ntim khoom thiab muab tus kov rau kev ua haujlwm ntxiv kom kho cov yam ntxwv ntawm cov khoom.

Organic Synthesis Intermediate
Raws li cov khoom siv hluav taws xob ntau yam, cov khoom siv no koom nrog ntau qhov kev hloov pauv xws li N-alkylation, N-acylation, thiab condensation reactions. Cov urea tuaj yeem hloov mus rau carbodiimides lossis guanidine rau kev piav qhia ntxiv. Cov tshuaj chlorine atom ua rau palladium-catalyzed cross-couplings xws li Suzuki thiab Buchwald-Hartwig cov tshuaj tiv thaiv, tso cai rau kev tsim kho ntawm ntau nyuaj aryl-urea derivatives rau kev tshawb fawb tshuaj thiab agrochemical. Nws cov khoom siv txuas ntxiv mus rau kev sib txuas ntawm cov khoom siv ua haujlwm uas cov urea moiety imparts hydrogen- kev sib txuas muaj peev xwm thiab lub koom haum tsim.

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