Tert-Butyl (2-phenylcyclopropyl) carbamate

N-Boc-2-phenylcyclopropylamine yog dawb los tawm- cov hmoov dawb crystalline nrog lub melting point ntawm 178-182℃.Nws qhia tau hais tias me ntsis solubility hauv dej tab sis yog yooj yim soluble nyob rau hauv polar organic solvents xws li methanol, ethanol (DMF), tetrahydrofurate. Solubility yog pom nyob rau hauv ethyl acetate.Nws yog ruaj khov nyob rau hauv qhuav tej yam kev mob ntawm chav tsev kub.Lub molecule muaj ib tug strained cyclopropane nplhaib fused rau ib tug phenyl pab pawg neeg thiab ib tug tert -butoxycarbonyl (Boc)- tiv thaiv thawj amine.Lub cyclopropane nplhaib yog ruaj khov, tab sis nyob rau hauv kev ruaj ntseg tej yam kev mob. hydrogenation tshaj PtO₂) lossis nrog qee yam electrophiles.Cov pab pawg Boc yog acid-labile.

O-Boc-2-phenylcyclopropylamine(CAS No.92644-77-4) yog chiral, non-proteinogenic amine qhov twg cov amino pawg tau txuas rau lub nplhaib cyclopropane uas yog vicinal rau ib qho phenyl hloov.Cov pawg Boc tiv thaiv cov amine .Qhov no contraindications siv rau contraindications thiab hloov kho cov khoom pharmacokinetic ntawm bioactive molecules.

1.Chiral Ligand rau Asymmetric Synthesis
Tom qab deprotection, cov dawb amine yog condensed nrog chiral aldehydes (piv txwv li, los ntawm pinene) kom ruaj khov, C₂-symmetric Schiff puag ligands.Cov ligands, thaum complexed nrog titanium los yog txhuas, catalyze heev enantioselective Strecker thiab {the cyanosilylation} cov tshuaj tiv thaiv.

2.Covalent Inhibitor Scaffold rau MAOs
Lub cyclopropylamine moiety yog ib tug paub mechanism-raws li inactivator ntawm monoamine oxidases (MAOs).This Boc- tiv thaiv precursor yog siv los ua ke prodrugs thiab fluorescently tagged sojntsuam los kawm txog cov enzyme inactivation kinetics thiab localization ntawm MAO-4}A thiab MAO.

3.Monomer rau Stimuli-Responsive Polyamines
Cov pab pawg Boc raug tshem tawm, thiab qhov tshwm sim thawj amine yog polymerized los ntawm kauj ruam -kev loj hlob polymerization nrog diacid chlorides los yog diisocyanates.Lub cyclopropane rings nyob rau hauv cov pob txha polymer qhia nro, ua rau cov polymers uas raug mob txha caj qaum thiab cov khoom hloov nyob rau hauv teb rau mechanical force (mechanophores) los yog redox stimuli.

4.Building Block rau CRTH2 Receptor Antagonists
Cov tshuaj no yog ib tug ncaj precursor nyob rau hauv lub multi-theem synthesis ntawm muaj zog thiab xaiv antagonists rau cov chemoattractant receptor-homologous molecule qhia ntawm Th2 hlwb (CRTH2), lub hom phiaj rau allergic hawb pob thiab rhinitis kho.The phenylcyclopropylamine receptor binding tseem ceeb.

Cim npe nrov: Tuam Tshoj tert-butyl (2-phenylcyclopropyl) carbamate manufacturers, lwm tus neeg